Anti-Human ICAM-1/CD54 Reference Antibody (Mor102, RUO)

Catalog No.	HY321046
Brand	abinScience
Host species	Human
Species reactivity	Human
Form	Liquid
Storage buffer	0.01M PBS pH 7.4
Purity	>95% purity as determined by SDS-PAGE.
Clonality	Monoclonal
Isotype	Fab-G4-nd
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Target	ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1
References	1. Boehncke WH, et al. Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol. 2005;153(4):758-766. [HY321046] 2. Mrowietz U, et al. Leukocyte adhesion: a suitable target for anti-inflammatory drugs. Curr Pharm Des. 2006;12(22):2825-2831. [HY321046]
Purification	Protein A/G purified from cell culture supernatant.
Biological activity	MOR102 (0.04-10 ug/mL; 30 min) potently inhibits adhesion of human SKW-3 T-cell leukaemia cells to immobilized recombinant ICAM-1 with an IC 50 of 3 nM [1]. MOR102 (0.5-50 ug/mL; 4 days) reduces proliferation of human peripheral blood mononuclear cells in mixed lymphocyte cultures [1]. MOR102 (10 ug/mL; overnight) binds to human HaCaT keratinocytes, with increased binding observed on IFN-γ-stimulated HaCaT cells [1]. MOR102 (10 mg/kg; i.p.; every alternate day; 4 weeks from day 22-50 after transplantation) significantly reduces epidermal thickness and inflammatory infiltrate in a psoriasis- SCID mouse model [1]. MOR102 (10 mg/kg; i.p.; every other day; 4 weeks) induces orthokeratotic differentiation, reduces epidermal thickness, and decreases inflammatory infiltrate in human chronic plaque-stage psoriasis skin grafts on SCID mice [2].
Endotoxin level	< 10 EU/mg
Expression system	Mammalian cells
Accession	P05362
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative name	MOR102
Note	For research use only. Not suitable for clinical or therapeutic use.