Anti-Human CD277/BTN3A1 Reference Antibody (CTX 2026, RUO)

Catalog No.

HT139016

Brand

abinScience

Host species

Human

Species reactivity

Human

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Purity

>95% purity as determined by SDS-PAGE.

Clonality

Monoclonal

Isotype

IgG1

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Target

BTF5, BTN3A1, Butyrophilin subfamily 3 member A1, CD277

References

1. Payne KK, et al. BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Science. 2020 Aug 21;369(6506):942-949. [HT139016]

Purification

Protein A/G purified from cell culture supernatant.

Biological activity

CTX-2026 (1 ug/mL; 12 h) redirects the cytotoxic activity of Vγ9Vδ2 T cells from multiple donors against BTN3A1 + OVCAR3 cells or primary HGSOC cells [1]. CTX-2026 (1 ug/mL; 6 d) shows a rescuing effect on nonablated CD45 + T cells [1]. CTX-2026 (5 mg/kg; i.p. for 15 days every 3 days once) effects the tumor growth of NY-OVCAR3 tumor mice [1].

Endotoxin level

< 10 EU/mg

Expression system

Mammalian cells

Accession

O00481

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative name

CTX-2026

Clone ID

CTX 2026

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Note

For research use only. Not suitable for clinical or therapeutic use.