Anti-Human ADAMTS5 Reference Antibody (CRB0017, RUO)

Catalog No.	HV374036
Brand	abinScience
Host species	Human
Species reactivity	Human
Form	Liquid
Storage buffer	0.01M PBS pH 7.4
Purity	>95% purity as determined by SDS-PAGE.
Clonality	Monoclonal
Isotype	IgG
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Target	ADAMTS11, ADAM-TS 11, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAMTS-11, ADMP2, ADAM-TS 5, ADAMTS-5, ADMP-2, ADAMTS5, Aggrecanase-2, ADAM-TS5, A disintegrin and metalloproteinase with thrombospondin motifs 5
References	1. Chiusaroli R, et al. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage. 2013;21(11):1807-1810. [HV374036]
Purification	Protein A/G purified from cell culture supernatant.
Biological activity	CRB0017 (1.2-12 mg per knee; intra-articular administration; 2 doses total, with a 6-week interval) significantly reduces all histopathological osteoarthritis (OA) scores in male STR/ort mice at the dose of 12 mg per knee [1].
Endotoxin level	< 10 EU/mg
Expression system	Mammalian cells
Accession	Q9UNA0
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative name	CRB0017
Clone ID	CRB0017
Note	For research use only. Not suitable for clinical or therapeutic use.