Anti-Human BST-2/Tetherin Reference Antibody (XmAb 5592, RUO)

Catalog No.	HC341016
Brand	abinScience
Host species	Human
Species reactivity	Human
Form	Liquid
Storage buffer	0.01M PBS pH 7.4
Purity	>95% purity as determined by SDS-PAGE.
Clonality	Monoclonal
Isotype	IgG
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Target	Tetherin, Bone marrow stromal antigen 2, BST2, BST-2, CD317, HM1.24 antigen
References	1. Tai YT, et, al. Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function. Blood. 2012 Mar 1;119(9):2074-82. [HC341016]
Purification	Protein A/G purified from cell culture supernatant.
Biological activity	via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP) [1].. XmAb 5592 significantly augments ADCC relative to the IgG1 analog against all cell lines ranged from 5-27 ng/mL, also augments antibody dependent cellular phagocytosis (ADCP) by macrophages [1]. XmAb 5592 (0-10000 ng/mL) induces strong MM cell lysis by degranulation of NK cells even in the presence of bone marrow stromal cells (BMSCs) [1]. XmAb 5592 (0.3-9 mg/kg; i.p.; twice weekly for 7 doses; SCID mice with palpable RPMI8226 tumors) inhibits tumor growth in mice bearing human MM xenografts via FcγR-dependent mechanisms [1].
Endotoxin level	< 10 EU/mg
Expression system	Mammalian cells
Accession	Q10589
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative name	XmAb-5592, XmAb5592, XmAb5592
Clone ID	XmAb 5592
Note	For research use only. Not suitable for clinical or therapeutic use.