Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (BMS936561, RUO)

Catalog No.

HW717046

Brand

abinScience

Host species

Human

Species reactivity

Human

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Purity

>95% purity as determined by SDS-PAGE.

Clonality

Monoclonal

Isotype

IgG

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Target

CD27 ligand, CD70, TNFSF7, CD27LG, CD27L, CD70 antigen, Tumor necrosis factor ligand superfamily member 7, CD27-L

References

1. Owonikoko TK, et al. First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70. Cancer Chemother Pharmacol. 2016 Jan;77(1):155-62. [HW717046]

Purification

Protein A/G purified from cell culture supernatant.

Biological activity

CD70 (TNFSF7) is a type II transmembrane glycoprotein belonging to the tumor necrosis factor superfamily and serves as the specific ligand for CD27. It mediates T and B cell activation, proliferation, and immune regulation; notably, it is aberrantly overexpressed in various tumors, making it a highly promising target for cancer immunotherapy.

Endotoxin level

< 10 EU/mg

Expression system

Mammalian cells

Accession

P32970

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative name

BMS936561, MDX-1115, MDX-1203

Clone ID

BMS936561

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Note

For research use only. Not suitable for clinical or therapeutic use.