Anti-Human GITR/TNFRSF18 Reference Antibody (FPA154, RUO)

Catalog No.	HV475066
Brand	abinScience
Host species	Human
Species reactivity	Human
Form	Liquid
Storage buffer	0.01M PBS pH 7.4
Purity	>95% purity as determined by SDS-PAGE.
Clonality	Monoclonal
Isotype	IgG
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Target	Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein
References	1. Susannah D. Barbee, et al. Abstract 613: Development of FPA154, a novel tetravalent anti-GITR antibody, for the treatment of solid tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 613. [HV475066]
Purification	Protein A/G purified from cell culture supernatant.
Biological activity	FPA154 can potently exert antibody-dependent cell-mediated cytotoxicity against regulatory T cells that highly express GITR [1].
Endotoxin level	< 10 EU/mg
Expression system	Mammalian cells
Accession	Q9Y5U5
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative name	FPA154
Clone ID	FPA154
Note	For research use only. Not suitable for clinical or therapeutic use.