| Catalog No. | HY515026 |
| Brand | abinScience |
| Host species | Human |
| Species reactivity | Human |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 |
| Purity | >95% purity as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Isotype | IgG2 |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | CD115, CSF-1 receptor, CSF1R, M-CSF-R, CSF-1-R, Proto-oncogene c-Fms, Macrophage colony-stimulating factor 1 receptor, CSF-1R, FMS |
| References | 1. Papadopoulos KP, et al. First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Oct 1;23(19):5703-5710. [HY515026] |
| Purification | Protein A/G purified from cell culture supernatant. |
| Biological activity | AMG-820 potently inhibits CSF1-driven proliferation of human bone marrow–derived monocytic cells, as well as CSF1- and IL34-driven proliferation of myelomonocytic AML-5 cells [1]. |
| Endotoxin level | < 10 EU/mg |
| Expression system | Mammalian cells |
| Accession | P07333 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternative name | AMG-820, AMG820, AMG820 |
| Clone ID | AMG 820 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Anti-Human M-CSF Reference Antibody (AMG 820, RUO)
Overview
Images
 SDS-PAGE |
SDS-PAGE for Research Grade Anti-Human CD115/CSF1R Antibody (AMG 820) |