| Catalog No. | HV219016 |
| Brand | abinScience |
| Species reactivity | Human |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 |
| Purity | >95% purity as determined by SDS-PAGE. |
| Isotype | IgG1-kappa |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | TREM1, Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1, TREM-1, CD354 |
| References | 1. Oladapo Yeku, et al. Evaluation of myeloid targeting agents, PY159 and PY314, in two dose expansion phase Ib trials in platinum-resistant ovarian cancer. December 2023. Immuno-Oncology Technology. [HV219016] 2. Yeku OO, et al. Myeloid targeting antibodies PY159 and PY314 for platinum-resistant ovarian cancer. J Immunother Cancer. 2025;13(3):e010959. Published 2025 Mar 13. [HV219016] 3. Nadine Jahchan, et al. Tuning the tumor microenvironment by reprogramming TREM1+ myeloid cells to unleash anti-tumor immunity in solid tumors. Journal for ImmunoTherapy of Cancer. November 2021. 9(Suppl 3):A900-A900 [HV219016] 4. Ira Seth Winer, et al. A phase 1a dose-escalation study of PY159, a monoclonal antibody targeting TREM1 (triggering receptor expressed on myeloid cells 1). J Clin Oncol 41, 2523-2523(2023). View More [HV219016] |
| Purification | Protein A/G purified from cell culture supernatant. |
| Biological activity | PY159 induceS signaling, upregulate monocyte activation markers, and stimulate proinflammatory cytokine production in human whole blood and dissociated primary tumor cells in vitro [3]. |
| Endotoxin level | < 10 EU/mg |
| Expression system | Mammalian cells |
| Accession | Q9NP99 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternative name | PY159 |
| Clone ID | PY159 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307) |
Anti-Human TREM-1 Reference Antibody (PY159, RUO)
Overview
Images
 Bioactivity |
Detects Human CD354/TREM1 in indirect ELISAs. |
 SDS-PAGE |
SDS-PAGE for Research Grade Anti-Human CD354/TREM1 (PY159). |
 Western blot |
Western blot analysis was performed using anti-CD354/TREM1 monoclonal antibody at 1μg/ml on various samples. Lane 1: recombinant human CD354/TREM1 (Catalog No: HV219012), 50ng Lane 2: recombinant human CD354/TREM1 (Catalog No: HV219012), 30ng |