Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO)

Catalog No.	HV811026
Brand	abinScience
Host species	Human
Species reactivity	Human
Form	Liquid
Storage buffer	0.01M PBS pH 7.4
Purity	>95% purity as determined by SDS-PAGE.
Clonality	Monoclonal
Isotype	IgG
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Target	FGF-inducible 14, TNFRSF12A, FN14, CD266, TweakR, Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, Tumor necrosis factor receptor superfamily member 12A
References	1. Berndt S, et al. Abstract 1210: Preclinical pharmacology and repeated dose toxicity of the novel agonistic TWEAK receptor binding antibody BAY-356. Cancer Res. 2016;76(14_Supplement):1210. [HV811026] 2. Viberg A, et al. Abstract 2089: Therapeutic index prediction of the agonistic aglycosylated TWEAK receptor binding antibody BAY-356. Cancer Res. 2016;76(14_Supplement):2089. [HV811026]
Purification	Protein A/G purified from cell culture supernatant.
Biological activity	BAY-356 induces dose-dependent agonistic effects in TWEAK receptor-positive tumor cells, activating NFκB and STAT1 pathways, increasing TWEAKR expression and IL-8 secretion, activating caspase 3/7, and inhibiting proliferation [1]. BAY-356 (3-10 mg/kg; twice weekly; up to 3 weeks) inhibits tumor growth by 49-71% in TWEAK receptor-positive solid tumor xenograft models [1]. BAY-356 (1-40 mg/kg; i.v.; weekly; 4 weeks) at 10 mg/kg results in well-tolerated exposure in healthy Cynomolgus monkeys, with higher doses (20 and 40 mg/kg) causing slight to moderate organ toxicity [2].
Endotoxin level	< 10 EU/mg
Expression system	Mammalian cells
Accession	Q9NP84
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative name	BAY-356, BAY356, BAY356
Clone ID	BAY-356
Note	For research use only. Not suitable for clinical or therapeutic use.