| Catalog No. | HP719016 |
| Brand | abinScience |
| Host species | Human |
| Species reactivity | General |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 |
| Purity | >95% purity as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Isotype | IgG |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | Phosphocholine, Phosphorylcholine, ChoP |
| References | 1. Harnett W, et al. Phosphorylcholine: friend or foe of the immune system? Immunol Today. 1999 Mar;20(3):125-9. [HP719016] 2. Tu S, et al., Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine. Macromol Biosci. 2011 Oct 10;11(10):1416-25. [HP719016] 3. Cansev M, et al., Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur J Pharmacol. 2008 Jul 28;589(1-3):315-22. [HP719016] 4. Caligiuri G, et al., Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol. 2007 Aug 7;50(6):540-6. View More [HP719016] |
| Purification | Protein A/G purified from cell culture supernatant. |
| Biological activity | Phosphorylcholine is a component of drug delivery micelles, which improves the efficiency of cellular internalization and increases the cytotoxicity of cytotoxins carried in micelles in HeLa cells [2]. Phosphorylcholine (200-600 umol/kg; ip; single dose) activates nicotinic and muscarinic cholinergic neurotransmission, stimulates the activation of α2-adrenergic receptors, and increases plasma glucagon and choline concentrations, thereby stimulating peripheral autonomic nervous system activity [3]. Phosphorylcholine (2 ug; ip; once every two weeks for 4 months) induces the production of anti-PC and anti-oxLDL antibodies, increases mature B cells in the spleen, and reduces atherosclerotic lesions in the aortic root in mouse models [4]. |
| Endotoxin level | < 10 EU/mg |
| Expression system | Mammalian cells |
| Accession | ChEBI: 18132, CAS: 107-73-3 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternative name | ATH3G10, ATH3G10, ATH-3G10 |
| Clone ID | ATH3G10 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Anti-ChoPPhosphorylcholine Reference Antibody (ATH3G10, RUO)
Overview
Images
 SDS-PAGE |
SDS-PAGE for Research Grade Anti-ChoPPhosphorylcholine Antibody (ATH3G10) |