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Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity

Nature Immunology
https://doi.org/10.1038/s41590-026-02484-9

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HC513016 Anti-Human Notch-2&Notch-3 Reference Antibody (Tarextumab Tarextumab (HC513016) is a research-grade recombinant antibody targeting N2ICD. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns. N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3