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Local, but not circulating, complement C3 shapes immune checkpoint blockade efficacy by controlling myeloid cell infiltration

Nature Communications
https://doi.org/10.1038/s41467-026-75542-3

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HF636046 Anti-Human Complement C3 Reference Antibody (NGM621 Anti-Human Complement C3 Antibody (NGM621) (HF636046) is a research-grade recombinant antibody targeting C3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns. C3, ASP, Complement C3, C3adesArg, C3bc, CPAMD1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1