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HEK293T Human TIGIT Stable Cell Line (HS739818)

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规格：
  • 1 ml
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概述
货号HS739818
品牌abinScience
描述
HEK293T Human TIGIT Stable Cell Line (HS739818) is a stable cell line expressing TIGIT. Engineered for consistent, high-level target expression in research applications.
Highlights
  • ●Stable Expression — Engineered for consistent, high-level target expression.
Accession号Q495A1
应用FCM
种属Human
靶标TIGIT
性能Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
稳定性和存储Frozen in liquid nitrogen.
规格1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
背景

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.

1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627
2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388
3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116
4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
图片

  • Flow cytometry

    Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human TIGIT monoclonal antibody at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
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公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
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V₁ (起始体积)
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工作液
C₂ (终浓度)
×
V₂ (终体积)

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HEK293T Human TIGIT Stable Cell Line

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