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HEK293T Human CD203c/ENPP3 Stable Cell Line (HT018818)

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规格：
  • 1 ml
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概述
货号HT018818
品牌abinScience
描述
HEK293T Human CD203c/ENPP3 Stable Cell Line (HT018818) is a stable cell line expressing CD203c/ENPP3. Engineered for consistent, high-level target expression in research applications.
Highlights
  • ●Stable Expression — Engineered for consistent, high-level target expression.
Accession号O14638
应用FCM
种属Human
靶标CD203c/ENPP3
性能Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
稳定性和存储Frozen in liquid nitrogen.
规格1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
背景

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (CD203c/ENPP3) is a ~100 kDa protein. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response. 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells.

1. Gorelik, A. et al. (2018) The FEBS journal 285, 2481-2494. PMID: 29717535
2. Jin-Hua, P. et al. (1997) Genomics 45, 412-5. PMID: 9344668
3. Mardjuki, R. et al. (2024) Cell reports 43, 114209. PMID: 38749434
4. Vollmayer, P. et al. (2003) European journal of biochemistry 270, 2971-8. PMID: 12846830
5. Bühring, HJ. et al. (2001) Blood 97, 3303-5. PMID: 11342463
图片

  • Flow cytometry

    Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ENPP3 monoclonal antibody at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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HEK293T Human CD203c/ENPP3 Stable Cell Line

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