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Anti-Human S1PR4 Recombinant Antibody (SAA1540) (HF811013)

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规格:
  • 50ug
  • 100ug
  • 1mg
数量:
  • 概述

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概述
货号HF811013
品牌abinScience
种属反应性Human
应用ELISA
宿主Mouse
克隆类型Monoclonal
同种型IgG2a, kappa
克隆号SAA1540
靶标S1P receptor 4, S1P receptor Edg-6, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor 4, EDG6, Sphingosine 1-phosphate receptor Edg-6, S1P4, S1PR4
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号O95977
RRIDAnti-Human S1PR4 Antibody (SAA1540) (abinScience Cat# HF811013, RRID:AB_3727301)
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息
应用方法 稀释比例
ELISA 1:2000-1:20000
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Sphingosine 1-phosphate receptor 4 (S1PR4) is a ~41 kDa protein. G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway. Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, contributing to the inflammatory response. In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response.

NoteFor research use only.
图片
  • SDS-PAGE

    SDS-PAGE for Anti-Human S1PR4 Antibody (SAA1540)

参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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