

| 货号 | HF811013 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 种属反应性 | Human | ||||
| 应用 | ELISA | ||||
| 宿主 | Mouse | ||||
| 克隆类型 | Monoclonal | ||||
| 同种型 | IgG2a, kappa | ||||
| 克隆号 | SAA1540 | ||||
| 靶标 | S1P receptor 4, S1P receptor Edg-6, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor 4, EDG6, Sphingosine 1-phosphate receptor Edg-6, S1P4, S1PR4 | ||||
| 内毒素水平 | Please contact with the lab for this information. | ||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | O95977 | ||||
| RRID | Anti-Human S1PR4 Antibody (SAA1540) (abinScience Cat# HF811013, RRID:AB_3727301) | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Sphingosine 1-phosphate receptor 4 (S1PR4) is a ~41 kDa protein. G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway. Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, contributing to the inflammatory response. In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response. | ||||
| Note | For research use only. |

SDS-PAGE for Anti-Human S1PR4 Antibody (SAA1540)



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