

| 货号 | HB002013 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 种属反应性 | Human | ||||
| 应用 | ELISA | ||||
| 宿主 | Mouse | ||||
| 克隆类型 | Monoclonal | ||||
| 同种型 | IgG2a, kappa | ||||
| 克隆号 | SAA1577 | ||||
| 靶标 | Beta-3 adrenoreceptor, Beta-3 adrenoceptor, B3AR, ADRB3, Beta-3 adrenergic receptor, ADRB3R | ||||
| 内毒素水平 | Please contact with the lab for this information. | ||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | P13945 | ||||
| RRID | Anti-Human ADRB3 Antibody (SAA1577) (abinScience Cat# HB002013, RRID:AB_3727338) | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Beta-3 adrenergic receptor (ADRB3) is a ~43 kDa protein. G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis. Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. 1. Igawa, Y. et al. (1999) British journal of pharmacology 126, 819-25. PMID: 10188996 2. Emorine, LJ. et al. (1989) Science (New York, N.Y.) 245, 1118-21. PMID: 2570461 3. Candelore, MR. et al. (1996) Endocrinology 137, 2638-41. PMID: 8641219 4. Soeder, KJ. et al. (1999) The Journal of biological chemistry 274, 12017-22. PMID: 10207024 5. Gauthier, C. et al. (1998) The Journal of clinical investigation 102, 1377-84. PMID: 9769330 | ||||
| Note | For research use only. |

SDS-PAGE for Anti-Human ADRB3 Antibody (SAA1577)



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