| 靶标 | 12LO, 12S-LOX, Arachidonate (12S)-lipoxygenase, Platelet-type lipoxygenase 12, LOG12, Arachidonate (15S)-lipoxygenase, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, 12S-lipoxygenase, ALOX12, Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| 背景 | Polyunsaturated fatty acid lipoxygenase ALOX12 is a ~75 kDa protein. Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE. Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA. Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. 1. Prusakiewicz, JJ. et al. (2007) Archives of biochemistry and biophysics 464, 260-8. PMID: 174935783. Hada, T. et al. (1991) Biochimica et biophysica acta 1083, 89-93. PMID: 18516374. Perry, SC. et al. (2020) Journal of lipid research 61, 1087-1103. PMID: 324043345. Chen, XS. et al. (1993) European journal of biochemistry 214, 845-52. PMID: 83196936. Chen, XS. et al. (1993) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 7, 694-701. PMID: 85006947. Ikei, KN. et al. (2012) Journal of lipid research 53, 2546-59. PMID: 22984144 |
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