Anti-Human TIMD4/TIM-4 Recombinant Antibody (SAA1613) (HP042013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HP042013

abinScience

种属反应性

Human

ELISA

Mouse

Monoclonal

IgG2a, kappa

SAA1613

TIMD4, T-cell immunoglobulin mucin receptor 4, TIM-4, TIMD-4, T-cell membrane protein 4, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q96H15

Anti-Human TIMD4/TIM-4 Antibody (SAA1613) (abinScience Cat# HP042013, RRID:AB_3727374)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4/TIM-4) is a ~41 kDa protein. Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism.

1. Min, C. et al. (2020) Cell death & disease 11, 561. PMID: 32703939

2. Moon, B. et al. (2021) Cells 10. PMID: 34067457

3. Moon, B. et al. (2020) Cells 9. PMID: 32640697

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human TIMD4/TIM-4 Antibody (SAA1613)

产品说明书

Anti-Human TIMD4/TIM-4 Recombinant Antibody (SAA1613).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TIMD4/TIM-4 Recombinant Antibody (SAA1613) (HP042013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TIMD4/TIM-4 Recombinant Antibody (SAA1613) (HP042013)

概述

图片

参考文献

产品说明书

相关产品推荐

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