

| 货号 | HP618013 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 种属反应性 | Human | ||||
| 应用 | ELISA, WB | ||||
| 宿主 | Mouse | ||||
| 克隆类型 | Monoclonal | ||||
| 同种型 | IgG2a, kappa | ||||
| 克隆号 | SAA1758 | ||||
| 靶标 | E3 ubiquitin-protein ligase RNF43, RING finger protein 43, RING-type E3 ubiquitin transferase RNF43, RNF43 | ||||
| 内毒素水平 | Please contact with the lab for this information. | ||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | Q68DV7 | ||||
| RRID | Anti-Human RNF43 Antibody (SAA1758) (abinScience Cat# HP618013, RRID:AB_3727519) | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | E3 ubiquitin-protein ligase RNF43 is a ~85 kDa protein. E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. 1. Sugiura, T. et al. (2008) Experimental cell research 314, 1519-28. PMID: 18313049 2. Hao, HX. et al. (2012) Nature 485, 195-200. PMID: 22575959 3. Koo, BK. et al. (2012) Nature 488, 665-9. PMID: 22895187 | ||||
| Note | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |

Western blot analysis was performed using anti-mouse RNF43 monoclonal antibody at 1ug/mL on various samples.
Lane 1: ATG11865 200ng
Lane 2: negative control



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