Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HS720013

abinScience

种属反应性

Human

ELISA, WB

Human

Monoclonal

SAA1999

C6orf144, GDNF family receptor alpha-like, GFRAL

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q6UXV0

Anti-Human GFRAL Antibody (SAA1999) (abinScience Cat# HS720013, RRID:AB_3727911)
_x005F_x005F_x000D_

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958

7. Li, J. et al. (2019) eLife 8. PMID: 31535977

For research use only.

Isotype Control

Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

SDS-PAGE

SDS-PAGE for Anti-Human GFRAL Antibody (SAA1999).

产品说明书

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human GFR alpha-like Recombinant Antibody (SAA1999) (HS720013)

概述

图片

参考文献

产品说明书

相关产品推荐

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