Anti-Human MBTD1 IP Recombinant Antibody (SAA0210) (HC542013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HC542013

abinScience

种属反应性

Human

ELISA, IF, IP, IP-MS

Mouse

Monoclonal

SAA0210

MBTD1, MBT domain-containing protein 1

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q05BQ5

Anti-Human MBTD1 IP Antibody (SAA0210) (abinScience Cat# HC542013, RRID:AB_3729744)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

MBT domain-containing protein 1 (MBTD1) is a ~70 kDa protein. Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).

1. Jacquet, K. et al. (2016) Molecular cell 62, 409-421. PMID: 27153538

2. Zhang, H. et al. (2020) Cell reports 30, 3996-4002.e4. PMID: 32209463

3. Eryilmaz, J. et al. (2009) PloS one 4, e7274. PMID: 19841675

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human MBTD1 IP Antibody (SAA0210)

产品说明书

Anti-Human MBTD1 IP Recombinant Antibody (SAA0210).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MBTD1 IP Recombinant Antibody (SAA0210) (HC542013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MBTD1 IP Recombinant Antibody (SAA0210) (HC542013)

概述

图片

参考文献

产品说明书

相关产品推荐

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