

| 货号 | HP682013 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 种属反应性 | Human | ||||
| 应用 | ELISA, IF, IP | ||||
| 宿主 | Mouse | ||||
| 克隆类型 | Monoclonal | ||||
| 同种型 | IgG2a | ||||
| 克隆号 | SAA0216 | ||||
| 靶标 | [histone H3]-dimethyl-L-lysine(9) demethylase PHF8, KIAA1111, [histone H3]-dimethyl-L-lysine(36) demethylase PHF8, PHF8, ZNF422, Histone lysine demethylase PHF8, PHD finger protein 8 | ||||
| 内毒素水平 | Please contact with the lab for this information. | ||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | Q9UPP1 | ||||
| RRID | Anti-Human PHF8 IP Antibody (SAA0216) (abinScience Cat# HP682013, RRID:AB_3729750) | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Histone lysine demethylase PHF8 is a ~117 kDa protein. Histone lysine demethylase with selectivity for mono- and dimethylated residues. It plays an essential role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). 1. Loenarz, C. et al. (2010) Human molecular genetics 19, 217-22. PMID: 19843542 2. Zhu, Z. et al. (2010) Cell research 20, 794-801. PMID: 20531378 3. Qiu, J. et al. (2010) Cell research 20, 908-18. PMID: 20548336 4. Liu, W. et al. (2010) Nature 466, 508-12. PMID: 20622854 5. Yu, L. et al. (2010) Cell research 20, 166-73. PMID: 20101266 6. Feng, W. et al. (2010) Nature structural & molecular biology 17, 445-50. PMID: 20208542 7. Kleine-Kohlbrecher, D. et al. (2010) Molecular cell 38, 165-78. PMID: 20346720 8. Qi, HH. et al. (2010) Nature 466, 503-7. PMID: 20622853 9. Horton, JR. et al. (2010) Nature structural & molecular biology 17, 38-43. PMID: 20023638 | ||||
| Note | For research use only. |

SDS-PAGE for Anti-Human PHF8 IP Antibody (SAA0216)



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