

| 货号 | HT002013 | ||||||
|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||
| 种属反应性 | Human | ||||||
| 应用 | ELISA, IF, IP, WB | ||||||
| 宿主 | Mouse | ||||||
| 克隆类型 | Monoclonal | ||||||
| 同种型 | IgG1 | ||||||
| 克隆号 | SAA0218 | ||||||
| 靶标 | PRMT3, HRMT1L3, Protein arginine N-methyltransferase 3, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | ||||||
| 内毒素水平 | Please contact with the lab for this information. | ||||||
| 纯度 | >95% as determined by SDS-PAGE. | ||||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||||
| Accession号 | O60678 | ||||||
| RRID | Anti-Human PRMT3 IP Antibody (SAA0218) (abinScience Cat# HT002013, RRID:AB_3729752) | ||||||
| 状态 | Liquid | ||||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Protein arginine N-methyltransferase 3 (PRMT3) is a ~59 kDa protein. Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases. Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2. Also appears to methylate other ribosomal proteins. May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation. 1. Siarheyeva, A. et al. (2012) Structure (London, England : 1993) 20, 1425-35. PMID: 22795084 2. Liu, F. et al. (2013) Journal of medicinal chemistry 56, 2110-24. PMID: 23445220 3. Kaniskan, HÜ. et al. (2015) Angewandte Chemie (International ed. in English) 54, 5166-70. PMID: 25728001 4. Min, Z. et al. (2019) Cell death & disease 10, 581. PMID: 31378783 5. Verma, M. et al. (2021) Communications biology 4, 109. PMID: 33495566 6. Gupta, S. et al. (2024) The Biochemical journal 481, 1723-1740. PMID: 39513743 | ||||||
| Note | For research use only. |

SDS-PAGE for Anti-Human PRMT3 IP Antibody (SAA0218)



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