Anti-Human MTF2 IP Recombinant Antibody (SAA0253) (HP178013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HP178013

abinScience

种属反应性

Human

ELISA, IF, IP

Mouse

Monoclonal

IgG2a

SAA0253

hPCl2, Metal-response element-binding transcription factor 2, Polycomb-like protein 2, PCL2, MTF2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

Q9Y483

Anti-Human MTF2 IP Antibody (SAA0253) (abinScience Cat# HP178013, RRID:AB_3729787)

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Metal-response element-binding transcription factor 2 (MTF2) is a ~67 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally.

1. Musselman, CA. et al. (2012) Nature structural & molecular biology 19, 1266-72. PMID: 23142980

2. Qin, S. et al. (2013) Biochemical and biophysical research communications 430, 547-53. PMID: 23228662

3. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human MTF2 IP Antibody (SAA0253)

产品说明书

Anti-Human MTF2 IP Recombinant Antibody (SAA0253).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MTF2 IP Recombinant Antibody (SAA0253) (HP178013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MTF2 IP Recombinant Antibody (SAA0253) (HP178013)

概述

图片

参考文献

产品说明书

相关产品推荐

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