| 靶标 | Autoprotease p20, Capsid protein C, Cysteine protease NS2, E(rns) glycoprotein, EC:2.7.7.48, EC:3.4.21.113, EC:3.4.22.-, EC:3.6.1.15, EC:3.6.4.13, EC:4.6.1.19, Envelope glycoprotein E1, Envelope glycoprotein E2, Genome polyprotein, N-pro, N-terminal protease, NS4A, NS4B, NS5A, NS5B, Non-structural protein 2, Non-structural protein 2-3, Non-structural protein 3, Non-structural protein 4A, Non-structural protein 4B, Non-structural protein 5A, RNA-directed RNA polymerase, Serine protease NS3, Viroporin p7, gp33, gp44/48, gp55, p10, p14, p30, p54, p58, p75, p80 |
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| 背景 | Genome polyprotein (NS4B) is a ~449 kDa protein. Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation. |
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