| 靶标 | GRIN1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDAR1, hNR1 |
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| 背景 | Glutamate receptor ionotropic, NMDA 1 (GRIN1/NMDAR1) is a ~105 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hamdan, FF. et al. (2011) American journal of human genetics 88, 306-16. PMID: 213763003. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 269197614. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 281268515. Chen, W. et al. (2017) Journal of human genetics 62, 589-597. PMID: 282286396. Zhang, J. et al. (2023) Nature structural & molecular biology 30, 629-639. PMID: 369592617. Karp, SJ. et al. (1993) The Journal of biological chemistry 268, 3728-33. PMID: 76791158. Younkin, DP. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2174-8. PMID: 76815889. Planells-Cases, R. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 5057-61. PMID: 7685113 |
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