Anti-PTPN11 Polyclonal Antibody (HC400014)

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概述
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产品说明书

概述

货号

HC400014

品牌

abinScience

描述

Anti-PTPN11 Polyclonal Antibody (HC400014) is a rabbit polyclonal antibody detecting PTPN11 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human PTPN11 (Met1-Arg593).

靶标

Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-2C, Shp2, SHP-2, SH-PTP3, Protein-tyrosine phosphatase 2C, PTP2C, PTP-1D, PTPN11, SHPTP2, SH-PTP2

纯化方式

Purified by antigen affinity column.

Accession号

Q06124

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) is a ~68 kDa protein. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73.

1. Miao, H. et al. (2000) Nature cell biology 2, 62-9. PMID: 10655584

2. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

3. Lee, HH. et al. (2008) The Journal of cell biology 181, 999-1012. PMID: 18559669

4. Jakob, S. et al. (2008) The Journal of biological chemistry 283, 33155-61. PMID: 18829466

5. Noda, S. et al. (2016) Biochemical and biophysical research communications 469, 1133-9. PMID: 26742426

6. Pannone, L. et al. (2017) Human mutation 38, 451-459. PMID: 28074573

7. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441

Note

For research use only.

图片

参考文献

产品说明书

Anti-PTPN11 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PTPN11 Polyclonal Antibody (HC400014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PTPN11 Polyclonal Antibody (HC400014)

概述

图片

参考文献

产品说明书

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