Anti-NR1H3 Polyclonal Antibody (HC284014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC284014

品牌

abinScience

描述

Anti-NR1H3 Polyclonal Antibody (HC284014) is a rabbit polyclonal antibody detecting NR1H3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human NR1H3 (Asn95-Lys434).

靶标

Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR-alpha, NR1H3, Liver X receptor alpha, LXRA

纯化方式

Purified by antigen affinity column.

Accession号

Q13133

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Oxysterols receptor LXR-alpha (NR1H3) is a ~50 kDa protein. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.

1. Jakobsson, T. et al. (2009) Molecular cell 34, 510-8. PMID: 19481530

2. Sakurabashi, A. et al. (2015) The Journal of steroid biochemistry and molecular biology 149, 80-8. PMID: 25661920

3. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846

Note

For research use only.

图片

参考文献

产品说明书

Anti-NR1H3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NR1H3 Polyclonal Antibody (HC284014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NR1H3 Polyclonal Antibody (HC284014)

概述

图片

参考文献

产品说明书

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