Anti-PAK2 Polyclonal Antibody (HC597014)

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100ug

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概述
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产品说明书

概述

货号

HC597014

品牌

abinScience

描述

Anti-PAK2 Polyclonal Antibody (HC597014) is a rabbit polyclonal antibody detecting PAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human PAK2 (Glu177-Ala419).

靶标

S6/H4 kinase, p21-activated kinase 2, p58, PAK-2, PAK2, C-t-PAK2, PAK65, p34, Gamma-PAK, Serine/threonine-protein kinase PAK 2, p27

纯化方式

Purified by antigen affinity column.

Accession号

Q13177

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Serine/threonine-protein kinase PAK 2 (PAK2) is a ~58 kDa protein. Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.

1. Jakobi, R. et al. (2003) The Journal of biological chemistry 278, 38675-85. PMID: 12853446

2. Vilas, GL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6542-7. PMID: 16617111

3. Mitsushima, M. et al. (2009) Molecular and cellular biology 29, 2816-27. PMID: 19273597

4. Hsu, RM. et al. (2010) Molecular biology of the cell 21, 287-301. PMID: 19923322

5. Antonarakis, SE. et al. (2021) Human molecular genetics 31, 1-9. PMID: 33693784

6. Martin, GA. et al. (1995) The EMBO journal 14, 1970-8. PMID: 7744004

7. Rudel, T. et al. (1997) Science (New York, N.Y.) 276, 1571-4. PMID: 9171063

Note

For research use only.

图片

参考文献

产品说明书

Anti-PAK2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PAK2 Polyclonal Antibody (HC597014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PAK2 Polyclonal Antibody (HC597014)

概述

图片

参考文献

产品说明书

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