| 背景 | S-phase kinase-associated protein 2 (SKP2) is a ~47 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. 1. Yu, ZK. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 11324-9. PMID: 97367353. Tedesco, D. et al. (2002) Genes & development 16, 2946-57. PMID: 124356354. von der Lehr, N. et al. (2003) Molecular cell 11, 1189-200. PMID: 127698445. Li, X. et al. (2003) The Journal of biological chemistry 278, 30854-8. PMID: 128400336. Tokarz, S. et al. (2004) The Journal of biological chemistry 279, 46424-30. PMID: 153426347. Huang, H. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1649-54. PMID: 156683999. Barboric, M. et al. (2005) Journal of virology 79, 11135-41. PMID: 16103164 |
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