Anti-IRF5 Polyclonal Antibody (HC523014)

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概述
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产品说明书

概述

货号

HC523014

品牌

abinScience

描述

Anti-IRF5 Polyclonal Antibody (HC523014) is a rabbit polyclonal antibody detecting IRF5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human IRF5 (Glu232-Ala477).

靶标

IRF5, Interferon regulatory factor 5, IRF-5

纯化方式

Purified by antigen affinity column.

Accession号

Q13568

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Interferon regulatory factor 5 (IRF5) is a ~56 kDa protein. Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.

1. Barnes, BJ. et al. (2001) The Journal of biological chemistry 276, 23382-90. PMID: 11303025

2. Schoenemeyer, A. et al. (2005) The Journal of biological chemistry 280, 17005-12. PMID: 15695821

3. Chang Foreman, HC. et al. (2012) PloS one 7, e33098. PMID: 22412986

4. Lopez-Pelaez, M. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 17432-7. PMID: 25326418

5. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612

6. Yin, X. et al. (2021) Cell reports 34, 108628. PMID: 33440148

Note

For research use only.

图片

参考文献

产品说明书

Anti-IRF5 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IRF5 Polyclonal Antibody (HC523014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IRF5 Polyclonal Antibody (HC523014)

概述

图片

参考文献

产品说明书

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