Anti-TAB1 Polyclonal Antibody (HS933014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HS933014

品牌

abinScience

描述

Anti-TAB1 Polyclonal Antibody (HS933014) is a rabbit polyclonal antibody detecting TAB1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human TAB1 (Leu189-Pro439).

靶标

MAP3K7IP1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB1

纯化方式

Purified by antigen affinity column.

Accession号

Q15750

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a ~54 kDa protein. Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits.

1. Pathak, S. et al. (2012) The EMBO journal 31, 1394-404. PMID: 22307082

2. Yang, CY. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 1547-57. PMID: 24403530

3. Sakurai, H. et al. (2000) FEBS letters 474, 141-5. PMID: 10838074

4. Charlaftis, N. et al. (2014) The EMBO journal 33, 2581-96. PMID: 25260751

5. Ma, M. et al. (2023) Molecular cell 83, 3885-3903.e5. PMID: 37832545

6. Ge, B. et al. (2002) Science (New York, N.Y.) 295, 1291-4. PMID: 11847341

7. Thapa, D. et al. (2018) Molecular and cellular biology 38. PMID: 29229647

8. Cheung, PC. et al. (2003) The EMBO journal 22, 5793-805. PMID: 14592977

9. Mendoza, H. et al. (2008) The Biochemical journal 409, 711-22. PMID: 18021073

Note

For research use only.

图片

参考文献

产品说明书

Anti-TAB1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TAB1 Polyclonal Antibody (HS933014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TAB1 Polyclonal Antibody (HS933014)

概述

图片

参考文献

产品说明书

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