Anti-MPEG1 Polyclonal Antibody (HS702014)

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概述
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产品说明书

概述

货号

HS702014

品牌

abinScience

描述

Anti-MPEG1 Polyclonal Antibody (HS702014) is a rabbit polyclonal antibody detecting MPEG1 in ELISA, IHC, WB. Suitable for Human and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human MPEG1 (Phe313-Ser580).

靶标

Macrophage-expressed gene 1 protein, Perforin-2, Mpg-1, MPEG1, P-2, Macrophage gene 1 protein

纯化方式

Purified by antigen affinity column.

Accession号

Q2M385

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Macrophage-expressed gene 1 protein (MPEG1) is a ~78 kDa protein. Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.

1. Fields, KA. et al. (2013) Infection and immunity 81, 3045-54. PMID: 23753625

2. McCormack, RM. et al. (2015) eLife 4. PMID: 26402460

3. McCormack, RM. et al. (2017) JCI insight 2. PMID: 28422754

4. Strbo, N. et al. (2019) Experimental dermatology 28, 225-232. PMID: 30609079

5. Pang, SS. et al. (2019) Nature communications 10, 4288. PMID: 31537793

6. Merselis, LC. et al. (2020) Frontiers in immunology 11, 601584. PMID: 33224153

Note

For research use only.

图片

参考文献

产品说明书

Anti-MPEG1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-MPEG1 Polyclonal Antibody (HS702014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-MPEG1 Polyclonal Antibody (HS702014)

概述

图片

参考文献

产品说明书

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