| 靶标 | Regnase-1, MCPIP, Endoribonuclease ZC3H12A, Reg1, MCPIP-1, MCP-induced protein 1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A, MCPIP1, Monocyte chemotactic protein-induced protein 1 |
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| 背景 | Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. 1. Mizgalska, D. et al. (2009) The FEBS journal 276, 7386-99. PMID: 199093373. Xu, J. et al. (2012) Nucleic acids research 40, 6957-65. PMID: 225613754. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 261345605. Suzuki, HI. et al. (2011) Molecular cell 44, 424-36. PMID: 220551886. Roy, A. et al. (2013) American journal of physiology. Cell physiology 305, C1021-32. PMID: 240487337. Wang, W. et al. (2015) The Journal of biological chemistry 290, 13372-85. PMID: 25861989 |
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