Anti-NOTCH2NLA Polyclonal Antibody (HV351014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HV351014

品牌

abinScience

描述

Anti-NOTCH2NLA Polyclonal Antibody (HV351014) is a rabbit polyclonal antibody detecting NOTCH2NLA in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human NOTCH2NLA (Met1-Asn236).

靶标

Notch homolog 2 N-terminal-like protein A, NOTCH2NL, Notch homolog 2 N-terminal-like protein, N2N, NOTCH2NLA

纯化方式

Purified by antigen affinity column.

Accession号

Q7Z3S9

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) is a ~25 kDa protein. Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation.

1. Florio, M. et al. (2018) eLife 7. PMID: 29561261

2. Fiddes, IT. et al. (2018) Cell 173, 1356-1369.e22. PMID: 29856954

3. Suzuki, IK. et al. (2018) Cell 173, 1370-1384.e16. PMID: 29856955

Note

For research use only.

图片

参考文献

产品说明书

Anti-NOTCH2NLA Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NOTCH2NLA Polyclonal Antibody (HV351014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-NOTCH2NLA Polyclonal Antibody (HV351014)

概述

图片

参考文献

产品说明书

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