Anti-CIB1 Polyclonal Antibody (HV134014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HV134014

品牌

abinScience

描述

Anti-CIB1 Polyclonal Antibody (HV134014) is a rabbit polyclonal antibody detecting CIB1 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Ovis aries, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CIB1 (Gly2-Leu191).

靶标

CIBP, CIB1, Calcium- and integrin-binding protein, Calcium and integrin-binding protein 1, KIP, SIP2-28, DNA-PKcs-interacting protein, PRKDCIP, Calmyrin, CIB, Kinase-interacting protein, SNK-interacting protein 2-28

纯化方式

Purified by antigen affinity column.

Accession号

Q99828

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Calcium and integrin-binding protein 1 (CIB1) is a ~21 kDa protein. Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation.

1. de Jong, SJ. et al. (2018) The Journal of experimental medicine 215, 2289-2310. PMID: 30068544

2. Wu, CJ. et al. (2020) The Journal of biological chemistry 295, 16086-16099. PMID: 32917726

Note

For research use only.

图片

参考文献

产品说明书

Anti-CIB1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CIB1 Polyclonal Antibody (HV134014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CIB1 Polyclonal Antibody (HV134014)

概述

图片

参考文献

产品说明书

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