Anti-TRAF4 Polyclonal Antibody (HV470014)

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100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HV470014

品牌

abinScience

描述

Anti-TRAF4 Polyclonal Antibody (HV470014) is a rabbit polyclonal antibody detecting TRAF4 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human TRAF4 (Gln193-Asp444).

靶标

CART1, MLN62, RING finger protein 83, TRAF4, MLN 62, Cysteine-rich domain associated with RING and Traf domains protein 1, RNF83, Metastatic lymph node gene 62 protein, TNF receptor-associated factor 4

纯化方式

Purified by antigen affinity column.

Accession号

Q9BUZ4

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

TNF receptor-associated factor 4 (TRAF4) is a ~53 kDa protein. Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction.

1. Cai, G. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11531-11536. PMID: 30352854

2. Li, J. et al. (2019) Cell death and differentiation 26, 2652-2666. PMID: 31076633

3. Cen, S. et al. (2020) EBioMedicine 54, 102722. PMID: 32268273

4. Yu, W. et al. (2021) The Journal of biological chemistry 296, 100739. PMID: 33991522

5. Yu, X. et al. (2020) Journal of hematology & oncology 13, 40. PMID: 32357935

Note

For research use only.

图片

参考文献

产品说明书

Anti-TRAF4 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TRAF4 Polyclonal Antibody (HV470014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TRAF4 Polyclonal Antibody (HV470014)

概述

图片

参考文献

产品说明书

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