| 背景 | Sphingosine kinase 1 (SPHK1) is a ~42 kDa protein. Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion. 1. Gijsbers, S. et al. (2002) Biochimica et biophysica acta 1580, 1-8. PMID: 119230953. Wang, Z. et al. (2013) Structure (London, England : 1993) 21, 798-809. PMID: 236026594. Shen, H. et al. (2014) Nature cell biology 16, 652-62. PMID: 249293595. Lee, JY. et al. (2018) Nature communications 9, 1479. PMID: 296620566. Maceyka, M. et al. (2005) The Journal of biological chemistry 280, 37118-29. PMID: 161182197. Adada, MM. et al. (2013) The Journal of biological chemistry 288, 27667-27679. PMID: 239350968. Lima, S. et al. (2017) The Journal of biological chemistry 292, 3074-3088. PMID: 28049734 |
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