Anti-HDAC6 Polyclonal Antibody (HV287014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HV287014

品牌

abinScience

描述

Anti-HDAC6 Polyclonal Antibody (HV287014) is a rabbit polyclonal antibody detecting HDAC6 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human HDAC6 (Ser479-Arg835).

靶标

KIAA0901, Histone deacetylase 6, HDAC6, HD6, Tubulin-lysine deacetylase HDAC6

纯化方式

Purified by antigen affinity column.

Accession号

Q9UBN7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Protein deacetylase HDAC6 is a ~131 kDa protein. Deacetylates a wide range of non-histone substrates. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly via deacetylation of alpha-tubulin. Alpha-tubulin deacetylation results in destabilization of dynamic microtubules. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy.

1. Hubbert, C. et al. (2002) Nature 417, 455-8. PMID: 12024216

2. Parmigiani, RB. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 9633-8. PMID: 18606987

3. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

4. Zhang, M. et al. (2014) Molecular cell 55, 31-46. PMID: 24882211

5. Ran, J. et al. (2015) Scientific reports 5, 12917. PMID: 26246421

6. Wang, R. et al. (2019) The Journal of cell biology 218, 267-284. PMID: 30538141

7. You, Z. et al. (2019) Nature communications 10, 5792. PMID: 31857589

8. Zhang, M. et al. (2019) The Journal of biological chemistry 294, 5813-5826. PMID: 30770470

9. Sun, C. et al. (2024) Cells 13. PMID: 38534334

10. Jin, J. et al. (2025) Nature 637, 215-223. PMID: 39567688

Note

For research use only.

图片

参考文献

产品说明书

Anti-HDAC6 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HDAC6 Polyclonal Antibody (HV287014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HDAC6 Polyclonal Antibody (HV287014)

概述

图片

参考文献

产品说明书

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