Anti-APPL1 Polyclonal Antibody (HV723014)

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概述
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参考文献
产品说明书

概述

货号

HV723014

品牌

abinScience

描述

Anti-APPL1 Polyclonal Antibody (HV723014) is a rabbit polyclonal antibody detecting APPL1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human APPL1 (Phe404-Ser673).

靶标

APPL1, Dip13-alpha, APPL, DIP13A, DCC-interacting protein 13-alpha, KIAA1428, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1

纯化方式

Purified by antigen affinity column.

Accession号

Q9UKG1

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

DCC-interacting protein 13-alpha (APPL1) is a ~79 kDa protein. Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages.

1. Mitsuuchi, Y. et al. (1999) Oncogene 18, 4891-8. PMID: 10490823

2. Miaczynska, M. et al. (2004) Cell 116, 445-56. PMID: 15016378

3. Wang, C. et al. (2009) The Journal of biological chemistry 284, 31608-15. PMID: 19661063

4. Prudente, S. et al. (2015) American journal of human genetics 97, 177-85. PMID: 26073777

5. Song, J. et al. (2016) Oncotarget 7, 279-92. PMID: 26583432

6. Cheng, KK. et al. (2014) Diabetes 63, 3748-58. PMID: 24879834

Note

For research use only.

图片

参考文献

产品说明书

Anti-APPL1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-APPL1 Polyclonal Antibody (HV723014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-APPL1 Polyclonal Antibody (HV723014)

概述

图片

参考文献

产品说明书

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