| 靶标 | PADI4, Peptidylarginine deiminase IV, HL-60 PAD, PADI5, Protein-arginine deiminase type-4, Protein-arginine deiminase type IV, PDI5, PAD4 |
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| 背景 | Protein-arginine deiminase type-4 (PADI4) is a ~74 kDa protein. Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. 2. Wang, Y. et al. (2004) Science (New York, N.Y.) 306, 279-83. PMID: 153457773. Arita, K. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 5291-6. PMID: 165676354. Horikoshi, N. et al. (2011) Acta crystallographica. Section D, Biological crystallography 67, 112-8. PMID: 212455326. Lee, YH. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 3611-6. PMID: 15731352 |
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