Toll-like receptor 2 is a ~89 kDa protein. Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. 2. Lancioni, CL. et al. (2011) Infection and immunity 79, 663-73. PMID: 210788523. Brightbill, HD. et al. (1999) Science (New York, N.Y.) 285, 732-6. PMID: 104269954. Aliprantis, AO. et al. (1999) Science (New York, N.Y.) 285, 736-9. PMID: 104269965. Bulut, Y. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 987-94. PMID: 114411076. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 166222057. Drage, MG. et al. (2009) Cellular immunology 258, 29-37. PMID: 193627128. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 158093039. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211 | 
