Anti-ATP6AP2 Polyclonal Antibody (HF566014)

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概述
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参考文献
产品说明书

概述

货号

HF566014

品牌

abinScience

描述

Anti-ATP6AP2 Polyclonal Antibody (HF566014) is a rabbit polyclonal antibody detecting ATP6AP2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human ATP6AP2 (Asn17-Glu302).

靶标

Renin/prorenin receptor, ER-localized type I transmembrane adapter, ATPase H(+)-transporting lysosomal accessory protein 2, CAPER, ATP6M8-9, Embryonic liver differentiation factor 10, ATP6AP2, ATPase H(+)-transporting lysosomal-interacting protein 2, V-ATPase M8.9 subunit, ATP6IP2, Renin receptor, N14F, ELDF10, Vacuolar ATP synthase membrane sector-associated protein M8-9

纯化方式

Purified by antigen affinity column.

Accession号

O75787

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Renin receptor (ATP6AP2) is a ~39 kDa protein. Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.

1. Nguyen, G. et al. (2002) The Journal of clinical investigation 109, 1417-27. PMID: 12045255

2. Rujano, MA. et al. (2017) The Journal of experimental medicine 214, 3707-3729. PMID: 29127204

3. Jung, YS. et al. (2018) Nature cell biology 20, 1421-1433. PMID: 30374053

4. Su, W. et al. (2020) Viruses 12. PMID: 32276428

Note

For research use only.

图片

参考文献

产品说明书

Anti-ATP6AP2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ATP6AP2 Polyclonal Antibody (HF566014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ATP6AP2 Polyclonal Antibody (HF566014)

概述

图片

参考文献

产品说明书

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