

| 货号 | VK810014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-Lassa virus/LASV Protein Z Polyclonal Antibody (VK810014) is a rabbit polyclonal antibody detecting Protein Z in ELISA, IHC, WB. Suitable for Lassa virus.
Highlights
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| 种属反应性 | Lassa virus (LASV) | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 同种型 | IgG | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant Lassa virus/LASV (Gly2-Pro99). | ||||||||
| 靶标 | RING finger protein Z, Protein Z, Zinc-binding protein, Z | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | O73557 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RING finger protein Z is a ~10 kDa protein. Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. 1. Strecker, T. et al. (2003) Journal of virology 77, 10700-5. PMID: 12970458 2. Cornu, TI. et al. (2004) Journal of virology 78, 2979-83. PMID: 14990716 | ||||||||
| Note | For research use only. |

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