Anti-Human MICAL1 Polyclonal Antibody (HP691014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HP691014

品牌

abinScience

描述

Anti-Human MICAL1 Polyclonal Antibody (HP691014) is a rabbit polyclonal antibody detecting MICAL1 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Human, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human MICAL1 (Met1-Lys488).

靶标

NICAL, [F-actin]-monooxygenase MICAL1, MICAL1, MICAL-1, NEDD9-interacting protein with calponin homology and LIM domains, Molecule interacting with CasL protein 1, MICAL

纯化方式

Purified by antigen affinity column.

Accession号

Q8TDZ2

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

[F-actin]-monooxygenase MICAL1 is a ~117 kDa protein. Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections.

1. Wu, H. et al. (2018) Scientific reports 8, 937. PMID: 29343822

2. Zucchini, D. et al. (2011) Archives of biochemistry and biophysics 515, 1-13. PMID: 21864500

3. Vitali, T. et al. (2016) Archives of biochemistry and biophysics 593, 24-37. PMID: 26845023

4. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human MICAL1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MICAL1 Polyclonal Antibody (HP691014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MICAL1 Polyclonal Antibody (HP691014)

概述

图片

参考文献

产品说明书

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