Anti-Human NLRX1 Polyclonal Antibody (HP387014)

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概述
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产品说明书

概述

货号

HP387014

品牌

abinScience

描述

Anti-Human NLRX1 Polyclonal Antibody (HP387014) is a rabbit polyclonal antibody detecting NLRX1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human NLRX1 (Arg667-Ser975).

靶标

NLR family member X1, NOD5, Caterpiller protein 11.3, NOD9, Nucleotide-binding oligomerization domain protein 9, NLRX1, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, NOD26, CLR11.3

纯化方式

Purified by antigen affinity column.

Accession号

Q86UT6

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

NLR family member X1 (NLRX1) is a ~107 kDa protein. Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.

1. Moore, CB. et al. (2008) Nature 451, 573-7. PMID: 18200010

2. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352

3. Li, H. et al. (2016) Molecular immunology 76, 90-7. PMID: 27393910

4. Tattoli, I. et al. (2008) EMBO reports 9, 293-300. PMID: 18219313

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human NLRX1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NLRX1 Polyclonal Antibody (HP387014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human NLRX1 Polyclonal Antibody (HP387014)

概述

图片

参考文献

产品说明书

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