| 靶标 | Isopeptidase T-3, Deubiquitinating enzyme 13, ISOT-3, ISOT3, Ubiquitin-specific-processing protease 13, Ubiquitin carboxyl-terminal hydrolase 13, Ubiquitin thioesterase 13, USP13 |
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| 背景 | Ubiquitin carboxyl-terminal hydrolase 13 (USP13) is a ~97 kDa protein. Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. 1. Chen, M. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 9119-24. PMID: 215716474. Xie, W. et al. (2020) Cell reports 30, 2807-2819.e4. PMID: 321017535. Shin, J. et al. (2022) Molecular medicine (Cambridge, Mass.) 28, 164. PMID: 365856126. Yeh, HM. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 3328-36. PMID: 239402787. Sun, H. et al. (2017) Nature communications 8, 15534. PMID: 28534493 |
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