UDP-glucuronosyltransferase 2B7 (UGT2B7) is a ~60 kDa protein. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. 1. Samokyszyn, VM. et al. (2000) The Journal of biological chemistry 275, 6908-14. PMID: 107022512. Picard, N. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 139-46. PMID: 154701613. Lépine, J. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5222-32. PMID: 154722294. Miley, MJ. et al. (2007) Journal of molecular biology 369, 498-511. PMID: 174423415. Alonen, A. et al. (2008) Biochemical pharmacology 76, 763-72. PMID: 186745156. Itäaho, K. et al. (2008) Drug metabolism and disposition: the biological fate of chemicals 36, 2307-15. PMID: 187192407. Sten, T. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 417-23. PMID: 190229378. Sneitz, N. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 582-91. PMID: 232888679. Perreault, M. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 1616-20. PMID: 2375626510. Kallionpää, RA. et al. (2015) The Journal of steroid biochemistry and molecular biology 154, 104-11. PMID: 26220143 | 
