E3 ubiquitin-protein ligase Itchy homolog is a ~102 kDa protein. Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. Involved in the control of inflammatory signaling pathways. Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. 1. Winberg, G. et al. (2000) Molecular and cellular biology 20, 8526-35. PMID: 110461482. Marchese, A. et al. (2003) Developmental cell 5, 709-22. PMID: 146020723. Feng, L. et al. (2004) The Journal of biological chemistry 279, 29681-90. PMID: 150517265. Chastagner, P. et al. (2006) EMBO reports 7, 1147-53. PMID: 170285736. Lee, TL. et al. (2008) Biochemical and biophysical research communications 375, 326-30. PMID: 187184487. Scialpi, F. et al. (2008) Biochemical pharmacology 76, 1515-21. PMID: 187184498. Bhandari, D. et al. (2009) Molecular biology of the cell 20, 1324-39. PMID: 191163169. Tao, M. et al. (2009) Current biology : CB 19, 1255-63. PMID: 1959225110. You, F. et al. (2009) Nature immunology 10, 1300-8. PMID: 19881509 | 
