| 背景 | cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) is a ~40 kDa protein. Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. 1. Guan, H. et al. (2005) The Journal of biological chemistry 280, 9957-62. PMID: 156426942. D'Souza, T. et al. (2005) The Journal of biological chemistry 280, 26233-40. PMID: 159051763. Pasqualucci, L. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 395-400. PMID: 163878474. Xu, H. et al. (2008) Breast cancer research and treatment 107, 63-70. PMID: 173333345. Zhang, F. et al. (2007) The Journal of biological chemistry 282, 22460-71. PMID: 175659876. Xiao, B. et al. (2007) The Journal of biological chemistry 282, 30256-64. PMID: 176934127. Shirakawa, K. et al. (2008) Nature structural & molecular biology 15, 1184-91. PMID: 188364548. Wang, W. et al. (2010) Molecular and cellular biochemistry 338, 115-22. PMID: 199498379. Gambaryan, S. et al. (2010) The Journal of biological chemistry 285, 18352-63. PMID: 20356841 |
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